The first match on Friday night sees Espanyol entertain Rayo Vallecano, with the home side looking to build on the positive display they produced to draw 2-2 away to Celta Vigo last week.
With Raul de Tomas’ future still uncertain, it will be up to Joselu to lead the line against a rival that returns to Barcelona a week after their 0-0 draw in Camp Nou.
Sevilla have new central defender Tanguy Nianzou to strengthen their back line as they entertain Valladolid, who kicked off their return to the top-flight with a 3-0 home defeat to Villarreal.
Munir El Haddadi looks to be on the verge of leaving Sevilla to join Getafe.
Osasuna were positive and aggressive in their opening day win against Sevilla and have the chance to build on that with another home match against Cadiz.
Cadiz, who lost their opening day encounter 1-0 at home to Real Sociedad, are little changed from the side that struggled to survive last season.
Betis have been forced to sell central defender Marc Bartra to meet financial fair-play rules, but have still to inscribe six players into their squad, including new signings Luiz Henrique and Luiz Felipe, and goalkeeper Claudio Bravo.
The absence of those six players didn’t stop Betis from winning 3-0 at home to Elche on the opening day, but Mallorca showed in their 0-0 draw in Bilbao that they will be a tough nut to crack defensively this season.
Saturday ends with Real Madrid visiting Celta Vigo and Carlo Ancelotti is expected to continue with his policy of squad rotations after last weekend’s 2-1 win in Almeria.
Dani Carvajal is training again after injury, but Lucas Vazquez looks likely to continue at right back. It will be interesting to see if Marco Asensio, who is linked with a move away, gets a chance.
Athletic club Bilbao produced a bright display against Mallorca, but were hampered by their failure to score. Ernesto Valverde’s side are likely to find another defensive minded rival when Valencia visit San Mames on Sunday afternoon.
There is an attractive match in the Metropolitano when Atletico Madrid face Villarreal after both teams kicked off the season with 3-0 wins.
Alvaro Morata and Joao Felix were impressive on the opening day, while Villarreal have been weakened by the sale of Pervis Estupinan to Brighton.
There is also a big game in San Sebastian as Real Sociedad face Barca after the two sides had contrasting opening day fortunes. Real Sociedad won in Cadiz, while a new-look Barca were held by Rayo Vallecano.
Barca have still not been able to inscribe Jules Kounde into their squad and Sergio Busquets is suspended. Even though it is still early days, Xavi Hernandez needs an improved display and result to stop the pre-season feel-good factor fading away.
Monday’s matches see Elche and Almeria look to bounce back from opening day defeats in what is virtually a southeast derby. Newly promoted Girona entertain Getafe in another match between two sides who started the season with a defeat.